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A small addition of polyethylene glycol Lutrol E ,1,2-propylene glycolor glycerol allows the preparation temperature and sometimes also theconcentration of Cremophor RH 40 to be reduced. The following substances serve asexamples: General In common with other surfactants, Cremophor RH 40 may alter the rate ofabsorption of active substances.
However, it must be noted that strong bases or acids should not beadded, as otherwise the ester components may be saponified. Preview — Dark Matter by Blake Crouch. Home Documents Cremo Phor Rh Rate this book Clear rating 1 of 5 stars 2 of 5 stars 3 of 5 stars 4 of 5 stars 5 of 5 stars. ToxicityAcute toxicity The following values for the average lethal dose LD 50 with a seven-dayfollow-up period were determined for Cremophor RH If thefirst half of the water is added too quickly, the solution can become opal-escent.
Thanks for telling us about the problem. Vitamin A palmitate 1. Sign in to Goodreads to learn more about Coke7. Cremophor RH 40 is largely insensitive to water hardness. Coke7 rated a book liked it. Storage The drums in which Cremophor RH 40 is stored should be kept tightlyclosed. As the method of preparing the solubilizate is very important, the produc-tion of a I. As a result of hydration, the solution thickens, withthe viscosity attaining a maximum after about half of the water has beenadded.
Thewater, also heated to 60 65 C, is added very slowly with thorough stir-ring into this mixture. Packaging Drums of 40 kg capacity. This solution did not cause any inflammation. Likewise, no indications of a sensitizing effecton the skin of guinea pigs were observed in the Magnusson and Kligmanmaximization test J. Further addition of water then decreases the viscosity again. At elevatedtemperatures it forms clear mixtures with fatty acids and fatty alcohols. Solutions become cloudy as the temperature increases.
A feature of the solutionsthus obtained is their good stability.
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Message Compare books Block this user. Examples are essential oils andcertain drugs for oral and topical application. Compatibility with the skin Swab tests have demonstrated that Cremophor RH 40 is compatible withand mucous membranes human skin.
Attention is also drawn tolocal legislation concerning the handling of foodstuffs, food wrappings,cosmetics etc. Refresh and try again. The tolerance of Cremophor RH 40 was checked by intravenous adminis-tration in rats over a period of four weeks. Aqueous Cremophor RH 40 solutions can be sterilized by heating to C.
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Use as emulsifier Cremophor RH 40 is also very suitable as an emulsifying agent. The phases may eevolucija separate during steriliza-tion, but this can be remedied by agitating the solution while it is still hot. Coke7 wants to read. The stability of most solubilized vitamins is affected by light.
Note The data submitted in this publication are based on our current knowledgeand experience. Return to Book Page. Stability Pure Cremophor RH 40 is chemically very stable. Want to Read ljudskw Error rating book.
In order to ensure that clear, aqueous solutions are obtained, the fat-soluble vitamins must first be intimately mixed with the solubilizer.
Atlas of Human Anatomy by Frank H. For this reason, it is advisable to subjectpreparations containing Cremophor RH 40 to pharmacological and clinicaltests before they are released for general use. Coke7 rated a book really liked it. Alternatively, the warm mixture of the vitamin and Cremophor RH40 can be slowly stirred into the water, which results in a lower increase inintermediate viscosity.
The fact that the solubilizer has very little taste and odour is an asset for suchapplications.
If the containers are repeatedly opened, microorga-nisms may grow in the product, particularly if the equipment used is notsterile.