Klucel™ LF Pharma, SDS · TDS*. Klucel™ M CS, Klucel™ M CS has excellent film-forming properties and thickens non-aqueous systems and provide lubricious. Klucel hydroxypropylcellulose (HPC) provides a remarkable set of physical properties for tablet binding, modified release, and film coating. This unique polymer. Klucel hydroxypropylcellulose (HPC) is a nonionic water-soluble cellulose ether with Klucel HPC is soluble in many polar organic solvents and in water below.
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It was also observed that during extrusion process these formulations exhibited decreased die swelling. Conventional hardness testing was performed on tablets compressed at same compaction pressure kluecl a tableting press.
Import Data and Price of klucel lf pharm hydroxypropylcellulose | Zauba
An immiscible amorphous system would exhibit two Tgs whereas a miscible system exhibits a single Tg on a DSC run. Also, HME converts the drug and HPC to an amorphous form, leading to a subsequent increase in surface area for bonding between the tabletting excipients The extruded systems had an almost similar tabletting property to un-extruded blends. Physical stability evaluation performed using XRD and DSC studies confirmed physical stability of the model drug, suggesting applicability of HPC in stabilizing klucek forms by forming solid solutions.
Published online Sep 8. DSC studies have been employed to characterize miscibility of amorphous systems extensively National Center for Biotechnology InformationU. In our experiments, HPC provided a matrix for the drug and aided formation of solid extrudate rods that could be pelletized.
Pellets manufactured utilizing ELF polymer exhibited faster drug release in comparison to EF pellets. Solubility enhancement of poorly soluble drugs is an extensively researched area in the current pharmaceutical industry.
Import Data and Price of klucel lf pharm | Zauba
In vitro release profiles tablets from extruded matrices. Physicochemical characterization of hot melt extruded bicalutamide-polyvinylpyrrolidone solid dispersions. Tablet hardness evaluation—Extruded Vs Not-Extruded formulations. Combined use of ordered mesoporous silica and precipitation inhibitors for improved oral absorption of the poorly soluble weak base itraconazole. Addition of mannitol MNT further enhanced the release by forming micro-pores and increasing the porosity of the extrudates.
Microstructured ternary solid dispersions to improve carbamazepine solubility.
However, this technology comes with caveat that formulations that perform in vitro may fail in vivo. They were stored in nitrogen-filled plastic bags in a refrigerator until further evaluation.
HME also imparted physical properties to extruded systems that contributed toward better tabletting properties. Hot-melt extrusion HME is a versatile processing technology that ld be used for solubility enhancement, granulation, and as a physico-chemical stability imparting technology Compactibility Profiles Another advantage of using HME is the physical transformation of drug and excipients which influences tabletting behavior.
The area of the plot force to distance travelled can be utilized to calculate the work of failure W f which is the work done for diametrical breaking of tablet.
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We have also made an attempt to explain dissolution mechanisms that play a significant role in solubility enhancement. The influence of guaifenesin and ketoprofen on the properties of hot-melt extruded polyethylene oxide films.
Thermodynamic stability in solid solutions by HME that have low Tg values has been reported due to formation of a homogenously dispersed matrix and formation of hydrogen bonds between the drug and polymer 57 Ritonavir-PEG amorphous solid dispersions: Addition of mannitol significantly aided the extrusion and pelletizing process in these formulations.
The klucl matrices utilized in tablet formulations exhibited faster release in comparison to pellets due to particle size reduction of extrudates which not only increases the surface area for dissolution but also decreases the potential for formation of a release controlling swellable polymer matrix.
Klucel® Hydroxypropylcellulose LF
Solid dispersion of ketoprofen in pellets. HPC polymers are non-ionic hydrophilic polymers that undergo polymer-chain-length-dependent solubilization and can be used to enhance solubility or dissolution rate of poorly soluble drugs.
Another advantage of using HME is the physical transformation of drug and excipients which influences tabletting behavior. Drug Discov Today [Rev] ; 12 23— Properties kluccel hot-melt extruded theophylline tablets kluel poly vinyl acetate Drug Dev Ind Pharm. T3 and T4 tablets were compressed from un-extruded mixtures with blend compositions similar to H3 and H4 tablets.
ELF polymer, being more plastic, forms a denser compact on being compressed, thus slowing down the release due to decreased porosity HME conditions including barrel temperature and screw speeds were optimized for maximum yield and were set according to observations made from thermal studies. Drug and excipients were evaluated for thermal stability at high temperatures. It has been observed that such hydrophilic polymers solubilize at a faster rate leaving behind a super saturated drug in the media resulting in solution-mediated phase conversion A small molecule such as KPR lacks such viscoelastic characteristics and apparently might have resulted in unequal contraction, and hence development of fissures during cooling.